Endocrine Abstracts

Little has been published on the long-term management of thyrotoxicosis with antithyroid drugs (ATDs). We analysed 376 thyrotoxic subjects on the Morriston database since 2002. 170 had Graves’ disease, 181 toxic multinodular goitre (TMNG); in 25 the diagnosis was not recorded. When euthyroid subjects were requested to have annual thyroid function testing 42 (11%) had died. 111(30%) did not have TFT’s done in last two years. 135 graves’s cases were given ATDs whi...

Background: Recent NICE guidance recommends radioactive iodine as the first line treatment for relapsed thyrotoxicosis as it reportedly produces better control than long-term anti-thyroid drugs (ATDs).However, almost all studies of long-term ATDs relapse occurs after discontinuation of a medication. We present a retrospective analysis of efficacy of ATDs. Methods: Data of all patients with hyperthyroidism, attending Endocrinology clinic at Morriston Hosp...

Section 1: Case history: A 52 years old gentleman initially presented with visual field defect and headache due to a large multi-lobulated pituitary adenoma and underwent an endoscopic transsphenoidal sub-total resection in March 2018. Histology revealed a non-functioning adenoma with mitotic index Ki-67 of 3%–5%. His visual field defects resolved post-operatively and he was monitored with serial imaging. A year later he suffered a collapse at his GP surgery and was found...

Primary hyperparathyroidism (PHPT) is one of the common endocrine conditions and is frequently associated with hypertension and increased cardiovascular mortality but this association is not well recognised. The purpose of this study was to evaluate the effect of parathyroidectomy on blood pressure. The data of 112 patients who attended our out patients clinic over the period of 12 months, with the confirmed diagnosis of primary hyperparathyroidism was evaluated. Average age w...

Introduction: Risk of thyroid cancer is 17-32% in cold nodules and <1 % in hot nodules. Hot nodules are usually associated with Thyrotoxicosis. Patients with thyroid carcinoma are usually euthyroid but may be associated with hypothyroidism. We report 3 patients with hyperthyroidism and associated thyroid carcinoma.Case 1: A 17 years old lady presented with a lump in the neck and examination revealed prominent nodule on the right. TFTs were suggestive...

Introduction: Clinical practice guidelines advocate testing the aldosterone-renin ratio (ARR) in specific circumstances only. Tests should be taken following abstinence from drugs associated with false results. We aimed to determine the appropriateness of testing locally and any associated wasted healthcare costs.Methods: We retrospectively evaluated ARR requests taken July-October 2019 and July-October 2021 in Swansea Bay University Health Board to dete...

Introduction: Profound thyrotoxicosis commonly presents with heat intolerance, sweating, weight loss, palpitations, tremor, goitre and eye signs in the case of Grave’s disease. Typically, thyroid storm is differentiated by marked volume depletion, congestive cardiac failure, cardiac arrhythmias, confusion, nausea and vomiting, often with extreme agitation. The wide-ranging and systemic manifestations associated with profound hyperthyroidism are mediated through the thyroi...

Aim: To assess side effects of testosterone (TRT).Introduction: TRT in men with hypogonadism helps improve libido, erectile dysfunction, energy levels and bone density. However the risks/benefits of TRT in terms of ischemic heart disease (IHD), stroke and venous thromboembolism (VTE) is controversial no definitive answers from current evidence. We evaluated the side effects of TRT in patients attending endocrinology outpatient clinic between 2009 to 2019...

Aim: To compare efficacy of different formulations of TRT in treatment of hypogonadismBackground: Different formulations of testosterone are available for treatment of hypogonadism in men. TRT improves libido, sexual function, bone density and general well-being. We analysed data of 106 patients on TRT to compare efficacy of topical and injectable formulations.Methods: It’s a retrospective data analysis of 106 patient receivin...

Introduction: With the increased use of imaging modalities, detection of Adrenal Incidentaloma (AI) has become common.Aim: We evaluated management of patients with AI to improve service delivery.Method: Patients with AI referred to our endocrinology outpatient service (2006–2019). Data was collected from electronic case records and radiology reporting system. Demography, biochemical investigations, time interval between two sc...